PREPARATION OF SUPRAMOLECULAR COMPLEXES OF GOSSYPOL DERIVATIVES BASED ON GLYCYRRHIZIN ACID SALTS
Keywords:
Gossypol, primary amine, Schiff's base, substance, compound, licorice, triterpene glycoside, supramolecular complex.Abstract
Gossypol Schiff bases were synthesized and water-soluble supramolecular complexes of glycyrrhizic acid monoammonium salt (MASGA) in a ratio of 1:4 were obtained, taking into account the water insolubility of these substances. Some physico-chemical parameters of the complexes, their structure were studied by IR-, UV-spectra and computer calculation software.
References
А.И.Глушенкова, И.П.Назарова «Госсипол, его производные и их использование», Ташкент «ФАН», 1993 г., Стр.53.
Khaitbaev Kh. Alisher, Toshov S. Khamza, Nazirova K. Yayra. Researches on implementation in medical practice of supramolecular complex of megosin with MASGA. Journal of Medicinal and Chemical Sciences (J. Med. Chem. Sci.). 2019. №3. Р. 48-54.
Раджабова Г.Г., Рахматулина Н.Ш., Умарова Ф.Т., Левицкая Ю.В.,
Хаитбаев А.Х. и др. Изучение цитотоксического действия некоторых
комплексов глицирризиновой кислоты с производными госсипола. // ЎзМУ хабарлари.-№3/1.-2015.-С.8-10.
Барам Н.И., Зияев Х.Л., Исмаилов А.И., Зиямов Д., Мангутова Ю.С. Новые азопроизводные госсипола // Химия природных соединений. -Ташкент, 2000. - №5. - С.429.
Hakberdiev, S. M., Talipov, S. A., Dalimov, D. N., & Ibragimov, B. T. (2013).
,2′-Bis {8-[(benzylamino) methylidene]-1, 6-dihydroxy-5-isopropyl-3-methylnaphthalen-7 (8H)-one}. Acta Crystallographica Section E: Structure Reports Online, 69(11), o1626-o1627.
Khaitbaev A. K., Khakberdiev S. М., Toshov K. S. Isolation of Gossypol from the Bark of Cotton Roots //Annals of the Romanian Society for Cell Biology. – 2021. – С. 1069-1073.
Khamza, Toshov, Khakberdiev Shukhrat, and Khaitbaev Alisher. "X-ray structural analysis of gossypol derivatives." Journal of Critical Reviews 7.11 (2020): 460-463.
Толстикова Т.Г., Толстиков А.Г., Толстиков Г.А. На пути к низкодозным лекарствам // Вестник Российской академии наук. 2007. Т. 77. № 10. C. 867-874.
Khakberdiev, Sh M., et al. "Synthesis and structure of gossypol azomethine derivatives." Young Scientist,(4) (2015): 42-44.
Mahramovich, K. S. (2022). Results of computer study of biological activity of gossipol products. Web of Scientist: International Scientific Research Journal, 3(6), 1373-1378.
Mahramovich, K. S. (2023). Structural analysis of supramolecular complexes of schiff bases. American Journal of Interdisciplinary Research and Development, 12, 36-41.
Mahramovich, K. S., & Khodiyevich, K. S. (2023). Study of the practical significance of benzimidazole and some of its derivatives. Open Access Repository, 4(02), 80-85.
Mahramovich, K. S. (2024). Study of synthesis, structure and biological activity of gossypol derivatives in computer program. American Journal of Innovation in Science Research and Development, 1(2), 75-81.
Makhramovich, K. S. (2024). Synthesis of Schiff Bases, Supramolecular Complexes and their Influence on Macrophages. Miasto Przyszłości, 49, 922-926.
Khakberdiyev, S. M. (2024). Synthesis of aminopyridine derivatives based on gossypol. Miasto Przyszłości, 48, 1063-1068.
Mahramovich, K. S. (2024). Study of synthesis, structure and biological activity of gossypol derivatives in computer program. American Journal of Innovation in Science Research and Development, 1(2), 75-81.
