EKSPERIMENTAL TIREOTOKSIKOZ SHAROITIDA KALAMUSH QONIDAGI BIOKIMYOVIY KO'RSATKICHLARINING O'ZGARISHIGA AYRIM POLIFENOLLARNING KORREKSIYALOVCHI TA'SIRI
Keywords:
qalqonsimon bez (QB), tireotoksikoz (TT), tiroksin (T4), tiriyodotironin (T3), polifenol, kversetin, digidrokversetin, rutin, punitan.Abstract
Ushbu maqolada qalqonsimon bez faoliyatining buzilishi natijasida kelib chiqadigan tireotoksikoz patologiyasida organizmning biokimyoviy o`zgarishlari va uni qayta tiklash masalalari keltirildi. Tadqiqot ishida kversetin, rutin, digidrokversetin va punitan polifenollari korreksiyalovchi modda sifatida ishlatildi. Kversetin, rutin, digidrokversetin va punitan polifenollarining in vitro sharoitida eksperimental tireotoksikoz modelidagi (L-tiroksinning eritmasi 0,3mg/kg/kun) kalamushlarning qon zardobidagi biokimyoviy ko`rsatkichlari o`rganildi.
References
М.У.Сергалиева,Э.И. Абдулкадырова, А.Л. Ясенявская “Экспериментальные модели патологий щитовидной железы” 2020
Thyroid disorders in India: An epidemiological perspective/ Ambika Gopalakrishnan Unnikrishnan, Usha V. Menon /Indian Journal of Endocrinology and Metabolism / 2011 / Vol 15 / Supplement 2
Библиография Эндокринология: учебник / И. И. Дедов, Г. А. Мельниченко, В. В. Фадеев - М. : Литтерра, 2015. –
Ортиқов Х. А./Ёш физиологияси ва гигиена (бакалавриат босқичи касбий таълим йўналиши талабалари учун ўқув қўлланма ) – Самарқанд; 2010 – й., 228 бет.
Layal Chaker, David S Cooper, John P Walsh, Robin P Peeters//Hyperthyroidism//The Lancet Volume 403, Issue 10428, 24 February–1 March 2024, 768-780p
J.M. Berg, J.L.Tymoczko, L. Stryer/"Biochemistry"2002
Sh.I. Karimov//Xirurgik kasalliklar: tibbiyot oliy o'quv yurtlari talabalari uchun darslik. - Т.: Cho'lpon nashriyot-matbaa ijodiy uyi, - 488-b. ISBN 978-9943-05-406-6
Reitman, S. and Frankel, S. (1957)."A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases."American Journal of Clinical Pathology, 28(1): 56-63
Bergmeyer, H. U. (1986). Methods of Enzymatic Analysis, 3rd Edition.Verlag Chemie
Reitman, S. and Frankel, S. (1957)."A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases." American Journal of Clinical Pathology, 28(1): 56-63
Sharma, S. et al. (2019). Thyroid Disorders and Liver Dysfunction: A Review. Journal of Thyroid Research,Vasilenko, T. et al. (2020). The Impact of Hyperthyroidism on Liver Function. Endocrine Journal
