CARBAMATES AND BIS CARBAMATES IN MEDICINAL CHEMISTRY
Abstract
Organic carbamates play a crucial role in modern medicinal chemistry due to their stability, bioavailability, and functional versatility. This review explores their chemical properties, synthetic methodologies, and pharmacological applications. The analysis highlights their significance in protease inhibitors, neuroactive drugs, prodrugs, and anthelmintic agents. Advances in sustainable synthesis, particularly CO2-based carbonylation, enhance their applicability while addressing environmental concerns. Despite their advantages, hydrolytic instability remains a challenge, necessitating further research for improved structural modifications. Future advancements in carbamate-based therapeutics will drive innovation in drug design and development.
References
Ghosh, R., & Brindisi, M. (2015). Organic Carbamates in Drug Design and Medicinal Chemistry. Journal of Medicinal Chemistry, 58(7), 2895-2910.
Samadov, S.J., Nazarov, F.F., and Nazarov F.S. "Biological activity of syntezirovannyx soedineniy production n, npolymetilen bis [(no-aromatilo-cycloalkanoloilo) karbamatov]" Oriental renaissance: Innovative, educational, natural and social sciences, vol. 2, no. 4, 2022, pp. 895-898.
Гордеев Д.А. (2017). Бесфосгенный синтез алифатических карбаматов и изоцианатов на основе этиленкарбоната. Диссертация, Российский химико-технологический университет имени Д.И. Менделеева.
Махсумов А.Г., Абсалямова Г.М., Исмаилов Б.М., & Машаев Э.Э. (2019). Синтез и свойства производного – N,N'-гексаметилен бис-[(орто-аминоацетилфенокси)]-карбамата и его применение. Universum: химия и биология, (3(57)), 65-71.
Махсумов А.Г., Машаев Э.Э., Холбоев Ю.Х., Уразов Ф.Б., & Зохиджонов С.А. (2022). N,N'-гексаметилен бис[(м-крезолило)-карбамат] и его физико-химические свойства. Life Sciences and Agriculture, (1(9)), 7-11.
