ETIOPATHOGENESIS AND TREATMENT OF DRESS-SYNDROME

Abstract

The term "DRESS-syndrome "(drug-induced reaction with eosinophilia and systemic symptoms) appeared in therapeutic practice relatively recently – in 1996. However, anticonvulsant hypersensitivity syndrome, including exfoliative dermatitis, fever and eosinophilia, has been known since 1938. The abbreviation DIHS (drug-induced hypersensitivity)is also found in the literature. Currently, the prevalence of DRESS syndrome is estimated in the range of 1:3000-1: 10000 people, cases of the disease are noted in persons from 3 to 84 years old. Mortality in DRESS syndrome is 10-20%, which is due to both late diagnosis and severe multi-organ lesions.